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HESI A2 Chemistry Practice Questions: 25 Problems With Answers

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Naxles TeamOctober 13, 2026

HESI A2 Chemistry Practice Questions: 25 Problems With Answers

Chemistry can feel difficult when formulas and unfamiliar terminology appear together. A useful preparation strategy is to learn the basic ideas first: the structure of atoms, the periodic table, chemical bonding, mixtures, solutions, and simple calculations. The following original Naxles questions provide a starting point for revision. Check your program's requirements because not every nursing entrance exam includes the same science sections.

Practice questions

1. What is the smallest unit of an element that retains the chemical identity of that element?

Answer: A. Atom. An atom is the basic unit of a chemical element.

2. Which subatomic particle has a negative electrical charge?

Answer: C. Electron. Electrons carry negative charge; protons are positive and neutrons are neutral.

3. The atomic number of an element equals its number of:

Answer: A. Protons. The number of protons identifies the element.

4. Which bond involves the sharing of electron pairs between atoms?

Answer: A. Covalent bond. Covalent bonding involves shared electron pairs.

5. An ionic bond is primarily associated with:

Answer: A. Ionic compounds form through attraction between positive and negative ions.

6. What is the chemical formula for water?

Answer: B. H₂O. Each water molecule contains two hydrogen atoms and one oxygen atom.

7. What is the pH of a neutral aqueous solution at approximately 25°C?

Answer: C. 7. At approximately 25°C, neutral water has a pH near 7.

8. A solution with a pH of 3 is best described as:

Answer: A. Acidic. Values below 7 are acidic under the usual introductory chemistry model.

9. Which substance is a common example of an acid?

Answer: A. Hydrochloric acid. Hydrochloric acid releases hydrogen ions in aqueous solution.

10. What is a solute?

Answer: A. In a solution of salt water, salt is the solute and water is the solvent.

11. Which is an example of a mixture?

Answer: A. Air. Air contains several gases mixed together.

Answer: A. Air. Air contains several gases mixed together.

12. What is the approximate mass number of an atom?

Answer: A. The mass number is the total number of protons and neutrons in the nucleus.

13. What does a catalyst do?

Answer: A. A catalyst increases reaction rate without being consumed overall.

14. Which state of matter has a definite volume but takes the shape of its container?

Answer: B. Liquid. Liquids have a relatively definite volume but flow to match their container.

15. What is the symbol for sodium?

Answer: C. Na. Sodium's symbol comes from its Latin name, natrium.

16. Which formula represents carbon dioxide?

Answer: B. CO₂. Each molecule contains one carbon atom and two oxygen atoms.

17. How many atoms are represented in one molecule of H₂O?

Answer: C. 3. The molecule contains two hydrogen atoms and one oxygen atom.

18. What happens to the total mass in a closed system during an ordinary chemical reaction?

Answer: A. The law of conservation of mass states that total mass remains constant in a closed system during a chemical reaction.

Answer: A. The law of conservation of mass states that total mass remains constant in a closed system during a chemical reaction.

Answer: B. 18 g/mol. Two hydrogen atoms contribute about 2 g/mol and one oxygen atom about 16 g/mol.

20. What is the concentration in g/L of a solution containing 10 g of solute in 2 L of solution?

Answer: B. 5 g/L. Concentration =10 g÷2 L=5 g/L

21. What is an isotope?

Answer: A. Isotopes have the same proton number but different neutron numbers.

22. Which process changes a liquid into a gas at its surface?

Answer: A. Evaporation. Surface molecules gain enough energy to enter the gas phase.

23. What is the main difference between an element and a compound?

Answer: A. Compounds contain two or more elements chemically combined in defined proportions.

24. Which statement about acids and bases is generally correct?

Answer: A. Acid-base neutralization commonly produces water and a salt, depending on the reactants.

25. What is the coefficient of oxygen when the equation 2H 2 ​ +O 2 ​ →2H 2 ​ O is balanced?

Answer: A. 1. One oxygen molecule reacts with two hydrogen molecules to produce two water molecules.

Chemistry study strategy

Create a one-page reference sheet for common symbols, formulas, and definitions. Practice calculations by writing down the known values, selecting the appropriate relationship, and checking whether your answer has sensible units.

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